منابع مشابه
Identification of a Novel Function of CX-4945 as a Splicing Regulator
Alternative splicing is a nearly ubiquitous versatile process that controls gene expression and creates numerous protein isoforms with different functions from a single gene. The significance of alternative splicing has been confirmed by the increasing number of human diseases that are caused by misregulation of splicing events. Very few compounds, however, have been reported to act as inhibito...
متن کاملSplitting of certain spaces CX
There are a number of theorems to the effect that spaces of the form Q. n 11 n X split stably into wedges of simpler spaces when X is connected (by which we mean pathwise connected). The proofs generally proceed by exploitation of combinatorially manageable approximations for Q. n *L n X. The earliest theorem of this kind is due to Milnor(18), who exploited the semi-simplicial version of the Ja...
متن کاملEffects of the CK2 Inhibitors CX-4945 and CX-5011 on Drug-Resistant Cells
CK2 is a pleiotropic protein kinase, which regulates many survival pathways and plays a global anti-apoptotic function. It is highly expressed in tumor cells, and is presently considered a promising therapeutic target. Among the many inhibitors available for this kinase, the recently developed CX-4945 and CX-5011 have proved to be very potent, selective and effective in inducing cell death in t...
متن کاملCulex stigmatosoma and Cx. peus: identification of female adults in the United States.
Public reporting burden for the collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing the collection of information. Send comments regarding this burden estimate or any other aspect of this collection of information, including s...
متن کاملcx-AMINO ACIDS IN CHILDREN
The determination of the total content of free a-amino acids in urine has become routine in paediatric practice in numerous diseases. Interest in aminoaciduria has greatly increased since it became known that many congenital metabolic disorders are accompanied by an increased excretion of free oc-amino acids in the urine (Paine, 1960; Woolf, 1961). The excretion of free a-amino-N is usually exp...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1998
ISSN: 0021-9258
DOI: 10.1074/jbc.273.37.23799